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导演：保罗·费格
主演：桑德拉·布洛克 梅丽莎·麦卡西 德米安·比齐尔 马龙·韦恩斯 迈克尔·拉帕波特 斯波肯·瑞恩斯 迈克尔·麦克唐纳 丹·巴克达尔 比尔·伯尔 杰西卡·查芬 内森·科德里 塔兰·基拉姆 简·库丁
飞扬跋扈的FBI特工莎拉（桑德拉·布洛克 Sandra Bullock 饰）总是料事如神，屡建奇功，然而她强悍孤高的工作态度却令很多同事受不了，怨声载道的状况又再次阻碍了她的升职，莎拉的上司决定将其派到波士顿，并安排了一名新搭档穆林斯（梅丽莎·麦卡西 Melissa McCarthy 饰），共同追捕一个俄罗斯毒品集团，一方面发挥莎拉的机智，一方面则是考验她是否拥有与人协作的能力。然而这位新搭档偏偏也不是省油的灯，而是波士顿一名特立独行满口脏话的女警察，两个从未合作过的彪悍女性，开始了令人捧腹的磨合期，然而她们通力合作追捕罪犯的好戏才刚刚开始……Sarah Ashburn, an FBI agent, is extremely ambitious and has her eye on a promotion, but she doesn't get along with her co-workers. She is sent to Boston to uncover the identity of an elusive drug lord, Mr. Larkin, by tracking down his proxy, Rojas, and is told that she'll have a good shot at the promotion if she finds Larkin. When she arrives in Boston, she learns that Larkin has been eliminating his competition and taking over their operations. She learns that Rojas is in Boston PD custody and goes to see him to ask him what he knows about Larkin, but is warned that the cop who arrested Rojas, Shannon Mullins, is very territorial, and she is not exactly sociable. When the two meet they don't get along. When Mullins learns why Ashburn is in Boston, she decides to find Larkin herself. Ashburn is told by her boss to work with Mullins, but it won't be easy because Ashburn does things by the book while Mullins does things her way.